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BRIEF REPORT
Year : 2022  |  Volume : 7  |  Issue : 2  |  Page : 95-97

Elevated homocysteine and depression outcomes in patients with comorbid medical conditions in rural primary care


1 Department of Psychiatry, St. John's Medical College; Division of Mental Health and Neurosciences, St. John's Research Institute, Bengaluru, Karnataka, India
2 Department of Psychiatry, St. John's Medical College, Bengaluru, Karnataka, India
3 Department of Medicine, Division of Prevention Sciences, University of California, San Francisco, California, USA
4 Division of Mental Health and Neurosciences, St. John's Research Institute, Bengaluru, Karnataka, India; Department of Medicine, Division of Prevention Sciences, University of California, San Francisco, California, USA

Correspondence Address:
Dr. Krishnamachari Srinivasan
Department of Psychiatry, St. John's Medical College Hospital, Sarjapur Road, Bengaluru - 560 034, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jncd.jncd_18_22

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We examined the association of elevated concentration of total homocysteine (tHcy) with the severity of depression in patients diagnosed with depression and comorbid chronic medical conditions in rural primary care settings in Karnataka. Participants were included from the control arm of a cluster-randomized controlled trial designed to evaluate the effects of using a collaborative care model to integrate screening and treatment of primary health center patients. tHcy was assayed at baseline, and depression severity scores were assessed using the Patient Health Questionnaire (PHQ-9) 6 months later. There was no difference in the mean PHQ-9 score between those with (mean PHQ = 7.4) and without (mean PHQ = 7.6) elevated tHcy levels (P = 0.67).


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